Adverse reactions after propranolol withdrawal: Reply

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Plasma and atrial propranolol after preoperative withdrawal.

Of 34 patients scheduled for aortocoronary bypass operations who were withdrawn from chronic propranolol therapy between 18 and 48 hours before anesthesia and operation, propranolol was detected in the plasma of nine and in atrial tissue of five patients. Higher plasma levels were associated with higher propranolol intake and with shorter time of withdrawal. In 15 patients withdrawn preoperativ...

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Propranolol withdrawal syndrome - why?

FEW WHO HAVE WITNESSED the propranolol withdrawal phenomenon would deny its existence. The syndrome, which comprises the development of ventricular arrhythmias, severe angina, myocardial infarction and even death soon after sudden cessation of propranolol therapy, was first described in a series of case reports.' Perhaps the most convincing evidence was obtained by Miller et al.,6 who noted a 5...

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Mechanism of propranolol withdrawal phenomena.

Nine patients on chronic treatment with propranolol for essential hypertension for 3 months or longer were studied after abrupt discontinuation of the drug. Each patient demonstrated transient supersensitivity to the chronotropic effects of isoproterenol, beginning 2--6 days (median 4 days) after propranolol withdrawal, lasting for 3--13 days (median 6 days), with the maximum sensitivity on day...

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ژورنال

عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery

سال: 1974

ISSN: 0022-5223

DOI: 10.1016/s0022-5223(19)39751-x